PLX 647 dihydrochloride 是一种具有口服活性、高度特异性的双重 FMS 和 KIT 激酶抑制剂，IC50 分别为 28 和 16 nM。
货号:ajcx26922
CAS:1779796-38-1
分子式:C21H17F3N4.2HCl
分子量：455.3
溶解度:Soluble in DMSO
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Potent dual KIT/Fms inhibitor (IC50 values are 16 and 28 nM respectively). Inhibits BCR-FMS cell proliferation and osteoclast differentiation in vitro (IC50 values are 92 and 170 nM respectively). Attenuates LPS-induced TNFα and IL-6 release, mast cell activation and macrophage kidney proliferation in vivo.

Zhang et al (2013) Design and pharmacology of a highly specific dual FMS and KIT kinase inhibitor. Proc.Natl.Acad.Sci.U.S.A. 110 5689 PMID:23493555