ABP 688 是一种高亲和力人 mGluR5 拮抗剂，anKi 为 1.7 nM。
货号:ajcx26970
CAS:924298-51-1
分子式:C15H16N2O
分子量：240.3
溶解度:DMSO: 100 mM
纯度：98%
存储：Store at -20°C
库存：现货

Background:

High affinity human mGlu5 receptor antagonist (Ki = 1.7 nM). Inhibits glutamate-induced calcium release from L(tk-) cells expressing human mGlu5 receptors (IC50 = 2.3 nM).

Hintermann et al (2007) ABP688, a novel selective and high affinity ligand for the labeling of mGlu5 receptors: identification, in vitro pharmacology, pharmacokinetic and biodistribution studies. Bioorg.Med.Chem. 15 903 PMID:17110115