Biotinylated-JQ1 (Biotin-JQ1) 是 JQ1 的生物素化衍生物，可高亲和力结合到 BRD4 溴区。Biotinylated-JQ1 抑制 MM1.S 多发性骨髓瘤细胞增殖，EC50 为 0.4 μM。
货号:ajcx38300
CAS:1635437-52-3
分子式:C39H53ClN8O6S2
分子量：829.47
溶解度:DMSO : 180 mg/mL (217.01 mM; Need ultrasonic)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Biotinylated-JQ1 (Biotin-JQ1) is a biotinylated derivative of JQ1 with high affinity for the bromodomain of BRD4. Biotinylated-JQ1 inhibits MM1.S multiple myeloma cells proliferation with the EC50 of 0.4 μM[1].

Biotinylated-JQ1 (0.1 nM-100 μM; 72 hours) inhibits MM1.S cell proliferation with an EC50 of 0.4 μM[1].

[1]. Lars Anders, et al. Genome-wide localization of small molecules. Nat Biotechnol. 2014 Jan;32(1):92-6.