LIT-001 是第一种非肽类催产素受体 (OT-R) 激动剂 (EC50=55 nM; Ki=226 nM)。LIT-001 改善孤独症小鼠模型的社交互动。
货号:ajcx15628
CAS:2245072-21-1
分子式:C30H34F3N7O4S
分子量：645.7
溶解度:DMSO: 250 mg/mL (387.18 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

LIT-001 is the first nonpeptide oxytocin receptor (OT-R) agonist (EC50=55 nM; Ki=226 nM). LIT-001 improves social interaction in a mouse model of autism[1].

In vitro signaling experiments, LIT-001 is a nonbiased OT-R agonist on the two main signaling pathways of this receptor, with minor antagonist effect on V1a and agonist effect on V1b receptors, observed at high concentrations only[1].

LIT-001 (10-20 mg/kg; i.p.) alleviates core symptoms in the context of autism spectrum disorders (ASD )[1]. Animal Model: Oprm1-/- mice (bred in house on a 50% 129SVPas-50% C57BL/6J hybrid background)[1]

[1]. Frantz MC, et al. LIT-001, the First Nonpeptide Oxytocin Receptor Agonist that Improves Social Interaction in a Mouse Model of Autism. J Med Chem. 2018 Oct 11;61(19):8670-8692.