CDK8-IN-1是一个有效的、CDK8的选择性抑制剂，其IC50值为3nM。
货号:ajcx12888
CAS:1629633-48-2
分子式:C11H8F3N3O
分子量：255.2
溶解度:Soluble in DMSO
纯度：98%
存储：Store at -20°C
库存：现货

Background:

CDK8-IN-1 is a potent and selective CDK8 inhibitor with an IC50 of 3 nM.

CDK8-IN-1 displays low systemic clearance, very good exposure and oral bioavailability. The tmax is 0.25 h by PO. The mean values of Cmax are 9940 μg/L, 12740 μg/L by IV and PO respectively. The values of AUC are 9378, 25952 by IV and PO respectively[1].

[1]. Han X, et al. Discovery of potent and selective CDK8 inhibitors through FBDD approach. Bioorg Med Chem Lett. 2017 Sep 15;27(18):4488-4492.

Protocol:

Animal experiment:	Mice[1]CDK8-IN-1 is administrated to mice with 5 mg/kg, 25mg/mg by IV and PO respectively[1].
参考文献: [1]. Han X, et al. Discovery of potent and selective CDK8 inhibitors through FBDD approach. Bioorg Med Chem Lett. 2017 Sep 15;27(18):4488-4492.