High affinity and selective PCAF bromodomain inhibitor
货号:ajcx27484
CAS:N/A
分子式:C21H24N6.2HCl
分子量：433.38
溶解度:Soluble in DMSO
纯度：98%
存储：Store at -20°C
库存：现货

Background:

High affinity and selective cell-permeable p300/CBP-associated factor (PCAF) inhibitor (Ki = 47 nM). Exhibits no significant activity against a panel of 48 other bromodomains except GCN5 (Kd = 600 nM). Exhibits >4500-fold selectivity for PCAF over BRD4. Also exhibits metabolic stability in mouse and human liver microsomes and no observable cytotoxicity in peripheral blood mononuclear cells (PBMC).

Moustakim et al (2017) Discovery of a PCAF bromodomain chemical probe. Angew.Chem.Int.Ed. 56 827 PMID:27966810