C55H57ClFN7O8S
货号:ajcx28168
CAS:2230821-38-0
分子式:C55H57ClFN7O8S
分子量：1030.61
溶解度:DMSO|103.06|100|
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Potent EGFR Degrader (DC50 values are 39.2 nM for wild-type EGFR in OVCAR8 cells and 736 nM for Exon20Ins mutated EGFR in HeLa cells). Also degrades HER2. Comprises the EGFR inhibitor lapatinib? joined by a linker to a von Hippel-Lindau (VHL) recruiting ligand. Inhibits proliferation of HER2-driven breast cancer cell lines (IC50 = 102 nM for SKBr3 cells).