ARN077是一个有效的、选择性的N-乙酰乙醇胺酸酰胺酶(NAAA)抑制剂，其对人NAAAIC50值为7nM。ARN077能显著提高中枢神经系统中棕榈酰乙醇胺(PEA)的水平，对小鼠和大鼠具有广泛的镇痛活性。
货号:ajcx12700
CAS:1373625-34-3
分子式:C16H21NO4
分子量：291.34
溶解度:Soluble in DMSO
纯度：98%
存储：Store at -20°C
库存：现货

Background:

ARN 077 is a potent and selective N-acylethanolamine acid amidase (NAAA) inhibitor with an IC50 of 7 nM for human NAAA[1]. ARN 077 significantly increases palmitoyl ethanolamine (PEA) levels within the CNS and has broad antinociceptive activity in mice and rats[2].

[1]. Sasso O, et al. Antinociceptive effects of the N-acylethanolamine acid amidase inhibitor ARN077 in rodent pain models. Pain. 2013 Mar;154(3):350-60. [2]. Davis MP, et al. Cannabinoids in pain management: CB1, CB2 and non-classic receptor ligands. Expert Opin Investig Drugs. 2014 Aug;23(8):1123-40.