MK-0429是有效的integrin拮抗剂。IC50值为12.2nM(α5β1integrin)和2.8nM(αvβ3integrin)。
货号:ajcx12748
CAS:227963-15-7
分子式:C23H29N5O4
分子量：439.51
溶解度:DMSO : 250 mg/mL (568.82 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

MK-0429 is a potent integrin antagonist with IC50s of 12.2 nM (α5β1 integrin) and 2.8 nM (αvβ3 integrin), respectively.

[1]. Zhou X, et al. An integrin antagonist (MK-0429) decreases proteinuria and renal fibrosis in the ZSF1 rat diabetic nephropathy model.Pharmacol Res Perspect. 2017 Oct; 5 (5).