SC-VC-PAB-MMAE 是抗体偶联药物的一部分 (drug-linker conjugate for ADC),具有抗癌活性,它由 MMAE (一种 tubulin 抑制剂) 和可降解 (cleavable) 的 SC-VC-PAB linker 连接而成。
货号:ajcx16628
CAS:2259318-46-0
分子式:C68H105N11O17
分子量:1348.62
溶解度:DMSO: 100 mg/mL (74.15 mM)
纯度:98%
存储:Store at -20°C
库存:
现货Background:
SC-VC-PAB-MMAE is a drug-linker conjugate for ADC with potent antitumor activity by using the anti-mitotic agent, monomethyl auristatin E (MMAE, a tubulin inhibitor), linked via the cleavable linker SC-VC-PAB[1].
[1]. Brian Lannutti, et al. Ror1 antibody immunoconjugates. WO2018237335A1.