αvβ1 integrin-IN-1 TFA (Compound C8) 是一种有效的选择性 αvβ1 整合素抑制剂，IC50 为 0.63 nM。具有抗纤维化作用。
货号:ajcx33976
CAS:N/A
分子式:C28H35F3N6O8S
分子量：672.67
溶解度:DMSO : 250 mg/mL (371.65 mM; Need ultrasonic)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

αvβ1 integrin-IN-1 TFA (Compound C8) is a potent and selective αvβ1 integrin inhibitor with an IC50 of 0.63 nM. Antifibrotic effects[1].

αvβ1 integrin-IN-1 TFA (Compound C8) significantly reduces the fibrotic markers in mouse model for liver and lung fibrosis[1].

[1]. Reed NI, et al. Exploring N-Arylsulfonyl-l-proline Scaffold as a Platform for Potent and Selective αvβ1 Integrin Inhibitors. ACS Med Chem Lett. 2016 Aug 30;7(10):902-907.