SRI-29329 是特异性的 CLK 抑制剂，对CLK1、CLK2 和 CLK4 的IC50 值分别为 78 nM、16 nM 和 86 nM。
货号:ajcx35216
CAS:2086809-58-5
分子式:C20H26ClN7
分子量：399.92
溶解度:DMSO : 50 mg/mL (125.03 mM; Need ultrasonic)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

SRI-29329 is a specific CLK inhibitor, with IC50 values of 78 nM, 16 nM and 86 nM for CLK1, CLK2 and CLK4, respectively[1].

SRI-29329 (compound 8) shows some modest (~5 fold) selectivity for CLK2 over CLK1 and CLK4 without significant CDK1,4,6 activity[1].

[1]. Yihui Shi, et al. A triple exon-skipping luciferase reporter assay identifies a new CLK inhibitor pharmacophore. Bioorg Med Chem Lett. 2017 Feb 1;27(3):406-412.