TC JL 37 是一种有效的、选择性的、可口服的 TYK2 抑制剂，Ki 为 1.6 nM。
货号:ajcx27396
CAS:1258294-34-6
分子式:C17H11ClF2N4O2
分子量：376.74
溶解度:Soluble in DMSO
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Potent inhibitor of tyrosine kinase 2 (TYK2, Ki = 1.6 nM). Shows some selectivity for TYK2 over JAK1/2/3. Inhibits IFNγ production in vivo in mice. Orally bioavailable.

Liang et al (2013) Lead optimization of a 4-aminopyridine benzamide scaffold to identify potent, selective, and orally bioavailable TYK2 inhibitors. J.Med.Chem. 56 4521 PMID:23668484