Atorvastatin lactone is a prodrug form of atorvastatin, an HMG-CoA reductase inhibitor used to lower blood cholesterol levels.
CAS：125995-03-1
分子式：C33H33FN2O4
分子量：540.6
纯度：98%
存储：Store at -20°C

Background:

Atorvastatin lactone is a prodrug form of atorvastatin , an HMG-CoA reductase inhibitor used to lower blood cholesterol levels. The lactone hydrolyzes rapidly to the acid form of atorvastatin in human serum at room temperature. Atorvastatin lactone can also be formed in vivo from atorvastatin by certain uridine 5’-diphospho-glucuronosyltransferases. Like atorvastatin, the lactone inhibits P-glycoprotein in a concentration-dependent manner.