Top/HDAC-IN-1 (Compound 29b) 是一种拓扑异构酶 (Top)/HDAC双重抑制剂，对 HDAC1、HDAC2、HDAC3、HDAC6 和 HDAC8 的IC50分别为 18、230、790、87 和 5250 nM。Top/HDAC-IN-1 对 HCT116 细胞具有有效的抗肿瘤活性，IC50为 180 nM。Top/HDAC-IN-1 通过阻滞 G2 细胞周期有效诱导 HCT116 细胞凋亡 (Apoptosis)。

Top/HDAC-IN-1 (Compound 29b) is a topoisomerase / HDAC dual inhibitor with IC 50 s of 18, 230, 790, 87, and 5250 nM for HDAC1, HDAC2, HDAC3, HDAC6, and HDAC8, respectively. Top/HDAC-IN-1 exhibits potent antitumor activities against the HCT116 cell line with the IC 50 of 180 nM. Top/HDAC-IN-1 efficiently induces apoptosis with G2 cell cycle arrest in HCT116 cells [1].

C29H27N5O4

509.56

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years