BCP-T.A，一种杂环亲电子试剂，通过与GPX4结合而有效地诱导铁死亡 (Ferroptosis)。

BCP-T.A, a tunable heterocyclic electrophile, is a potent ferroptosis inducer by binding to GPX4 [1].

BCP-T.A induces ferroptosis in various cell lines (NCI-H522, T-1080, MDA-MB-468, MDA-MB-231, HeLa, HCT-116, U2OS, WI-38, and MEFS) with IC 50 values of 10 nM-367 nM [1]. BCP-T.A (0.5 μM, 3 h) binds to GPX4 and increases lipid peroxides, indicated by cellular thermal shift assay (CETSA) [1].

2786829-70-5

C23H19Cl2N3OS

456.39

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years