Artemisone 是一种半合成的有效抗疟疾剂,还是一种人CMV的有效抑制剂,可抑制多种P. falciparum,平均IC50值为 0.83 nM。
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描述
Artemisone is a potent and semi-synthetic antimalarial, inhibits P. falciparum strains (IC50: 0.83 nM). It also is a potent inhibitor of human CMV.
体外活性
Artemisone inhibits 3D7 and K1 P. falciparum (IC50s: 0.88±0.59 and 1.23±0.64 nM).
体内活性
Artemisone (3, 1, 0.3 and 0.1 mg/kg, s.c.) in combination with ohter antimalarials has enhanced effect against the chloroquine-resistant line P. yoelii NS[1] Artemisone is effectve at inhibiting the parasitaemia in the P. berghei NY susceptible strain, with an ED50 of 9.62 mg/kg via subcutaneous route and 11.67 mg/kg via oral administration[1].
Cas No.
255730-18-8
分子式
C19H31NO6S
分子量
401.52
别名
BAY 44-9585;青蒿酮;Artemifone
储存和溶解度
DMSO:130 mg/mL (323.77 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years