| CAS NO: | 33125-97-2 |
| 规格: | ≥98% |
| 包装 | 价格(元) |
| 25mg | 电议 |
| 50mg | 电议 |
| 100mg | 电议 |
| 250mg | 电议 |
| 500mg | 电议 |
| 1g | 电议 |
| 2g | 电议 |
| Molecular Weight (MW) | 244.29 |
|---|---|
| Formula | C14H16N2O2 |
| CAS No. | 33125-97-2 |
| Storage | -20℃ for 3 years in powder form |
| -80℃ for 2 years in solvent | |
| Solubility (In vitro) | DMSO: 49 mg/mL (200.6 mM) |
| Water: <1 mg/mL 49 | |
| Ethanol: 49 mg/mL (200.6 mM) | |
| Solubility (In vivo) | Chemical Name: ethyl 3-[(1R)-1-phenylethyl]imidazole-4-carboxylate InChi Key: NPUKDXXFDDZOKR-LLVKDONJSA-N InChi Code: InChI=1S/C14H16N2O2/c1-3-18-14(17)13-9-15-10-16(13)11(2)12-7-5-4-6-8-12/h4-11H,3H2,1-2H3/t11-/m1/s1 SMILES Code: O=C(C1=CN=CN1[C@@H](C2=CC=CC=C2)C)OCC |
| Synonyms | R 26490, Etomidate, Amidate, Ethomidate, Hypnomidate, R-26490, R26490, Radenarkon |
| In Vitro | In vitro activity: Etomidate rapidly increases phosphorylation of the extracellular signal-related kinases ERK1/2 in alpha2B-receptor-expressing HEK293 cells. Etomidate, via an increase in alpha5GABAAR activity, completely blocks long-term potentiation and impaired memory performance, and these effects are reversed by pretreatment with L-655,708. Etomidate directly activates GABA(A) receptors found in chromaffin cells thereby elevating [Ca(2+)](i). Etomidate modulates GABA(A) receptor activation by muscimol due to the positive anion equilibrium potential, depolarizes chromaffin cells. Etomidate (3-100 mM) suppresses glutamate uptake in a time- and concentration-dependent manner with a half-maximum effect occurring at 2.4 mM. Etomidate leads to a significant decrease of V(max) whereas the K(m) of the transporter is unaffected. |
|---|---|
| In Vivo | Etomidate results in a transient increase (duration 2.4 min) in arterial blood pressure in wild-type mice (17 mmHg). Etomidate (10(-4) M) also inhibits CH tracheal rings contraction in response to cumulative concentrations of CCh and KCl in chronically hypoxic rats. Etomidate and ketamine attenuates pulmonary vasorelaxation in response to acetylcholine and bradykinin, whereas they has no effect on the response to A23187 in canine pulmonary artery. Etomidate and ketamine further attenuates both L-NAME-resistant and TBA-resistant relaxation in canine pulmonary artery. |
| Animal model | Rats |
| Formulation & Dosage | N/A |
| References | Anesthesiology. 2003 Oct;99(4):889-95; Anesthesiology. 2009 Nov;111(5):1025-35; Anesth Analg. 2003 Apr;96(4):1035-41; Anesthesiology. 2001 Apr;94(4):668-77. |
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