Potassium oxonate 是用作尿酸酶抑制剂,都5-FU磷酸化为5-fluorouridine-5'-monophosphate具有抑制作用。
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描述
Oxonic Acid (potassium salt) is a uricase inhibitor that prevents metabolism and excretion of uric acid and induces embryotoxicity and nephrotoxicity in rats.
体内活性
Oxonic Acid? is a component of S-1, a mixture containing a prodrug of the antitumor agent 5-fluorouracil, that suppresses the gastrointestinal toxicity of 5-FU without inhibiting its antitumor activity in rats[1].Formulations containing oxonic acid have been used to treat gastric, pancreatic, lung, head, neck, and breast carcinomas[2].
Cas No.
2207-75-2
分子式
C4H2KN3O4
分子量
195.175
别名
Oxonic Acid (potassium salt);Potassium otastat;氧嗪酸钾;Potassium azaorotate
储存和溶解度
H2O:9.09 mg/mL (46.57 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years