TP-10 是 PDE10A 对其他 PDE 的特异性抑制剂，IC50 为 0.8 nM。

TP-10 is a selective inhibitor of PDE10A against other PDEs with IC50 of 0.8 nM.

TP-10 is active in the mouse behavioral model for positive symptoms. TP-10 demonstrates good in vitro and in vivo activity with extremely high intrinsic clearance (CLint) of t>1000 mL/min/kg in mouse liver microsomes (MLM) in assay[1].

898563-00-3

C26H19F3N4O

460.45

DMSO:95 mg/mL (206.32 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years