Ziprasidone HCl(CP-88059) - 半岛电竞官方网址

Molecular Weight (MW)	449.4
Formula	C21H21ClN4OS·HCl
CAS No.	122883-93-6
Storage	-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)	DMSO: 90 mg/mL (200.3 mM)
Water: <1 mg/mL
Ethanol: <1 mg/mL
SMILES Code	O=C1NC2=C(C=C(CCN3CCN(C4=NSC5=CC=CC=C45)CC3)C(Cl)=C2)C1.[H]Cl
Synonyms	CP-88059; CP88059; CP88059 mesylate; Ziprasidone mesylate, CP 88059; CP-88,059; CP-88,059-01; Geodon; Zeldox; Zipwell.

Molecular Weight (MW)

449.4

Formula

C21H21ClN4OS·HCl

CAS No.

122883-93-6

Storage

-20℃ for 3 years in powder form

-80℃ for 2 years in solvent

Solubility (In vitro)

DMSO: 90 mg/mL (200.3 mM)

Water: <1 mg/mL

Ethanol: <1 mg/mL

SMILES Code

O=C1NC2=C(C=C(CCN3CCN(C4=NSC5=CC=CC=C45)CC3)C(Cl)=C2)C1.[H]Cl

Synonyms

CP-88059; CP88059; CP88059 mesylate; Ziprasidone mesylate, CP 88059; CP-88,059; CP-88,059-01; Geodon; Zeldox; Zipwell.

In Vitro	In vitro activity: Ziprasidone has high affinity for human 5-HT receptors and for human dopamine D(2) receptors. Ziprasidone is a 5-HT(1A) receptor agonist and an antagonist at 5-HT(2A), 5-HT(2C) and 5-HT(1B/1D) receptors. Ziprasidone inhibits neuronal uptake of 5-HT and norepinephrine comparable to the antidepressant imipramine. Ziprasidone blocks wild-type hERG current in a voltage- and concentration-dependent manner with IC(50) of 120nM in stably transfected HEK-293 cells. Ziprasidone shows minimal tonic block of hERG current estimated during a depolarizing voltage (-20 or +30mV) or evaluated by the envelope of tails test (+30mV). Ziprasidone significantly increases the time constant of the slow component of hERG current deactivation (at -50mV).
In Vivo	Ziprasidone exhibits less potent block of wild-type hERG current with IC(50) of 2.8 mM in Xenopus oocytes. Ziprasidone suppresses the significant increases in food intake produced by olanzapine, indicating that it has an intrinsic protective mechanism against drug-induced increases in food intake in rats. Ziprasidone results in a notable increase in NGF and ChAT immunoreactivity in the dentate gyrus (DG), CA1, and CA3 areas of the hippocampus of rats. Ziprasidone dose-dependently slows raphe unit activity (ED50 = 300 mg/kg i.v.) as does the atypical antipsychotics clozapine (ED50 = 250 mg/kg i.v.) and olanzapine (ED50 = 1000 mg/kg i.v.) in anesthetized rats.
Animal model	Rats
Formulation & Dosage	N/A
References	Biochem Pharmacol. 2006 Jan 12;71(3):278-86; Eur J Pharmacol. 2004 Nov 28;505(1-3):253-4.

In Vitro

In vitro activity: Ziprasidone has high affinity for human 5-HT receptors and for human dopamine D(2) receptors. Ziprasidone is a 5-HT(1A) receptor agonist and an antagonist at 5-HT(2A), 5-HT(2C) and 5-HT(1B/1D) receptors. Ziprasidone inhibits neuronal uptake of 5-HT and norepinephrine comparable to the antidepressant imipramine. Ziprasidone blocks wild-type hERG current in a voltage- and concentration-dependent manner with IC(50) of 120nM in stably transfected HEK-293 cells. Ziprasidone shows minimal tonic block of hERG current estimated during a depolarizing voltage (-20 or +30mV) or evaluated by the envelope of tails test (+30mV). Ziprasidone significantly increases the time constant of the slow component of hERG current deactivation (at -50mV).

In Vivo

Ziprasidone exhibits less potent block of wild-type hERG current with IC(50) of 2.8 mM in Xenopus oocytes. Ziprasidone suppresses the significant increases in food intake produced by olanzapine, indicating that it has an intrinsic protective mechanism against drug-induced increases in food intake in rats. Ziprasidone results in a notable increase in NGF and ChAT immunoreactivity in the dentate gyrus (DG), CA1, and CA3 areas of the hippocampus of rats. Ziprasidone dose-dependently slows raphe unit activity (ED50 = 300 mg/kg i.v.) as does the atypical antipsychotics clozapine (ED50 = 250 mg/kg i.v.) and olanzapine (ED50 = 1000 mg/kg i.v.) in anesthetized rats.

Animal model

Rats

Formulation & Dosage

N/A

References

Biochem Pharmacol. 2006 Jan 12;71(3):278-86; Eur J Pharmacol. 2004 Nov 28;505(1-3):253-4.

CAS NO:	122883-93-6
规格:	≥98%

包装	价格(元)
250mg	电议
500mg	电议
1g	电议
2g	电议
5g	电议
10g	电议