KY02111 is a canonicalWNTsignaling (β-catenin)inhibitor which promotes differentiation of hPSCs to cardiomyocytes. KY02111 can be used for the research of human cardiomyocyte regeneration^[1].

KY02111 promotes differentiation by inhibiting WNT signaling in hPSCs^[1].
KY02111 induces cardiomyocytes expressed the cardiac markers, αMHC, NKH2.5, and HCN4^[1].
KY02111 (1-10 μM; 12 hours, 24 hours) reduces WNT signaling in both IMR90-1 cells and HEK293 cells in a dose-dependent manner^[1].
KY02111 treatment with WNT signaling modulators produces robust cardiac differentiation of hPSCs in a xeno-free, defined medium, devoid of serum and any kind of recombinant cytokines and hormones, such as BMP4, Activin A, or insulin^[1].

376.86

Solid

C₁₈H₁₇ClN₂O₃S

1118807-13-8

Room temperature in continental US; may vary elsewhere.

DMSO : 33.33 mg/mL(88.44 mM;Need ultrasonic)

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