CAY10640 (compound TCPU ) 是一种有效的口服活性 sEH（可溶性环氧化物水解酶）抑制剂，在人和鼠中的 IC50 分别为 0.4 和 5.3 nM。
| Cas No. | 1208549-68-1 |
| 化学名 | N-[1-(cyclopropylcarbonyl)-4-piperidinyl]-N'-[4-(trifluoromethoxy)phenyl]-urea |
| Canonical SMILES | O=C(NC1CCN(C(C2CC2)=O)CC1)NC3=CC=C(OC(F)(F)F)C=C3 |
| 分子式 | C17H20F3N3O3 |
| 分子量 | 371.4 |
| 溶解度 | DMF: 5 mg/ml,DMSO: 5 mg/ml,DMSO:PBS(pH7.2) (1:1): 0.5 mg/ml,Ethanol: 2 mg/ml,PBS (pH 7.2): Isoluble |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
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描述 | Soluble epoxide hydrolase (sEH) inhibitors have important therapeutic use by increasing the in vivo concentration of EETs and other fatty acid epoxides, resulting in anti-inflammatory, antihypertensive, neuroprotective, and cardioprotective effects. CAY10640 is a 1-aryl-3-(1-acylpiperidin-4-yl)urea analog that inhibits recombinant human and mouse sEH with IC50 values both equal to 0.4 nM. CAY10640 demonstrates a 1,000-fold increase in potency compared to morphine in reducing hyperalgesia in an in vivo carrageenan-induced inflammatory pain model. |
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