Naftopidil DiHCl (KT-611 dihydrochloride) 是一种选择性 alpha1-adrenoceptor 拮抗剂，对克隆人 α1a-, ⋱1b- 和 α1d-adrenoceptor subtypes 的 Kis 分别为 3.7 nM，20 nM 和 1.2 nM。 Naftpidil DiHCl 具有抗增殖作用。 Naftpidil DiHCl可用于前列腺增生的研究。
| Cas No. | 57149-08-3 |
| 别名 | 盐酸萘哌地尔,KT-611 dihydrochloride; BM-15275 dihydrochloride |
| 化学名 | 1-[4-(2-methoxyphenyl)piperazin-1-yl]-3-naphthalen-1-yloxypropan-2-ol;dihydrochloride |
| Canonical SMILES | COC1=CC=CC=C1N2CCN(CC2)CC(COC3=CC=CC4=CC=CC=C43)O.Cl.Cl |
| 分子式 | C24H28N2O3.2HCl |
| 分子量 | 465.41 |
| 溶解度 | Soluble in DMSO |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
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描述 | Naftopidil DiHCl is a selective 5-HT1A and α1-adrenergic receptor antagonist with IC50 of 0.1 μM and 0.2 μM, respectively. Phase 3. |
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