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Quinine hydrochloride dihydrate
本半岛bd体育手机客户端 不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Quinine hydrochloride dihydrate图片
CAS NO:6119-47-7
包装与价格：
包装价格(元)
10 mM * 1 mL in DMSO电议
500mg电议
5 g电议
10 g电议
50 g电议

半岛bd体育手机客户端 名称
奎宁盐酸盐二水合物
半岛bd体育手机客户端 介绍
Quinine hydrochloride dihydrate 具有口服活性，可用作抗疟疾研究。Quinine hydrochloride dihydrate 是一种钾离子通道 (potassium channel) 抑制剂，可抑制电压脉冲引起的 MT mSlo3 (KCa5.1) 通道 +100 mV 电流, 其IC50值为 169 μM。
生物活性

Quinine hydrochloride dihydrate (Qualaquin) is an orally active and can be used in anti-malarial studies. Quinine hydrochloride dihydrate is apotassium channelinhibitor that inhibits WT mouse Slo3 (KCa5.1) channel currents evoked by voltage pulses to +100 mV with anIC50of 169 μM[1][2].

体外研究
(In Vitro)

Quinine hydrochloride dihydrate (150 μM, 30 min) inhibits the proliferation and cytostatic effects of DENV (Dengue virus) in human hepatocarcinoma HepG2 cell line[1].
Quinine hydrochloride dihydrate (37.5-150 μM, 24 hours) significantly reduces viral DENV RNA and protein levels in a dose-dependent manner in human hepatocarcinoma HepG2 cell line[1].

Cell Proliferation Assay[1]

Cell Line:Human hepatocarcinoma cell line(HepG2)
Concentration:150 μM
Incubation Time:30 min
Result:Inhibited DENV virus replication with 19% yield compared to untreated. Reduced DENV-positive cells from 23.28% to 12.05% in a dose-dependent manner.
体内研究
(In Vivo)

Quinine hydrochloride dihydrate (oral gavage, 12 or 15 mg/kg, every week, 16 weeks) has some tumor suppressing effect on skin cancer in Swiss albino mice[2].
Quinine hydrochloride dihydrate (oral gavage, 10 mg/kg, everyday, 8 weeks) causes a decrease in the antioxidant defense system of rat testicular tissue such as SOD, CAT and GSH enzyme activity in male adult albino rats[3].

Animal Model:Swiss albino mice 7-8-weeks (weighing 24 g)[2]
Dosage:Swiss albino mice 7-8-weeks (weighing 24 g)[2]
Administration:Oral gavage; every week; 16 weeks
Result:Resulted in a significant reduction in tumor size and weight at 12 mg/kg and little effect at higher dose of 15 mg/kg.
Clinical Trial
分子量

396.91

性状

Solid

Formula

C20H29ClN2O4

CAS 号

6119-47-7

中文名称

奎宁盐酸盐二水合物

结构分类
  • Alkaloids
  • Quinoline Alkaloids
来源
  • Plants
  • Rubiaceae
  • Cinchona ledgeriana(Howard) Moens et Trim
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
In Vitro: 

DMSO : ≥ 100 mg/mL(251.95 mM)

H2O : 20 mg/mL(50.39 mM;Need ultrasonic)

*"≥" means soluble, but saturation unknown.

配制储备液
浓度溶剂体积质量1 mg5 mg10 mg
1 mM2.5195 mL12.5973 mL25.1946 mL
5 mM0.5039 mL2.5195 mL5.0389 mL
10 mM0.2519 mL1.2597 mL2.5195 mL
*

请根据半岛bd体育手机客户端 在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的半岛bd体育手机客户端 失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month (sealed storage, away from moisture)。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照In Vitro方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用； 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂： PBS

    Solubility: 2.6 mg/mL (6.55 mM); Clear solution; Need ultrasonic and warming and heat to 60℃

*以上所有助溶剂都可在本网站选购。
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