MS159 is a potent nuclear receptor binding SET structural domain protein 2 (NSD2)PROTACdegrader. MS159 inhibits the growth of tumour cells. MS159 is a useful chemical tool for exploring the role of NSD2 in health and disease^[1].

MS159 (0.5-10 μM, 48 h) can induce the degradation of NSD2 protein in a time- and dose-dependent manner while the induced NSD2 degradation is reversible in 293FT cells^[1].
MS159 (2.5 μM, 72 h) can effectively degrade NSD2 as well as IKZF1 and IKZF3 in multiple myeloma cell lines KMS11 and H929 while the degradation of IKZF1/3 is mediated through a ubiquitin-proteasome system (UPS-) and cereblon (CRBN-) dependent mechanism^[1].
MS159 (2.5 μM, 8 days) can effectively inhibit the growth of KMS11 and H929 multiple myeloma cells through induced NSD2 degradation^[1].

828.83

Solid

C₄₃H₄₀N₈O₁₀

Room temperature in continental US; may vary elsewhere.

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

DMSO : 50 mg/mL(60.33 mM;Need ultrasonic)

请根据半岛bd体育手机客户端 在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的半岛bd体育手机客户端 失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month (sealed storage, away from moisture and light)。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。