Tesaglitazar - 半岛电竞官方网址

您好，欢迎来到半岛游戏平台官网入口网址设备网！ [登录] [免费注册]

立即咨询

Tesaglitazar

本半岛bd体育手机客户端不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

251565-85-2

包装与价格：

半岛bd体育手机客户端介绍

Tesaglitazar 是一种双重过氧化物酶体增殖物激活受体 (PPAR) α/γ 激动剂，对 PPARγ 比对 PPARα 更有效，对大鼠 PPARα 和人 PPARα 的 EC50 分别为 13.4 μM 和 3.6 μM，对大鼠均约为 0.2 μM和人类 PPARγ。

Cas No.	251565-85-2
别名	(S)-2-乙氧基-3-{4-[2-(4-甲磺酰基苯基)-乙氧基-苯基]-丙酸
化学名	(S)-2-ethoxy-3-(4-(4-((methylsulfonyl)oxy)phenethoxy)phenyl)propanoic acid
Canonical SMILES	OC([C@H](CC(C=C1)=CC=C1OCCC(C=C2)=CC=C2OS(=O)(C)=O)OCC)=O
分子式	C₂₀H₂₄O₇S
分子量	408.47
溶解度	DMF: 50 mg/ml,DMSO: 50 mg/ml,DMSO:PBS(pH7.2) (1:1): 0.5 mg/ml,Ethanol: 10 mg/ml
储存条件	Desiccate at RT
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request
半岛bd体育手机客户端描述	Tesaglitazar is a dual peroxisome proliferator-activated receptor (PPAR) alpha/gamma agonist that is more potent on PPARγ than on PPARα, with EC50s of 13.4 μM and 3.6 μM for rat PPARα and human PPARα, respectively, and approximately 0.2 μM for both rat and human PPARγ. Tesaglitazar induces interstitial mesenchymal cell DNA synthesis and fibrosarcomas in subcutaneous tissues in rats[1]. References: [1]. Hellmold H, et al. Tesaglitazar, a PPARalpha/gamma agonist, induces interstitial mesenchymal cell DNA synthesis and fibrosarcomas in subcutaneous tissues in rats. Toxicol Sci. 2007 Jul;98(1):63-74.