蛋白质/抗原/多肽 >> 重组蛋白
重组CD300LB蛋白
半岛bd体育手机客户端 介绍
基因名：
CD300LB 半岛bd体育手机客户端 别名： CD300b； CLM-7； CLM7； CMRF35-A2； IREM-3； IREM3； TREM-5； TREM5； CD300LB； CD300 molecule like family member b； CD300 molecule like family member b； CMRF35-like molecule 7； CD300 antigen like family member B； immune receptor expressed on myeloid cells 3； leukocyte mono-Ig-like receptor 5； triggering receptor expressed on myeloid cells 5； 背景信息：
CD300LB, also known as CD300b, LMIR5, CLM-7, and IREM?3, is a glycoprotein member of the immunoglobulin superfamily. LMIR5 is expressed on the surface of myeloid lineage cells. It forms noncovalent cis?homodimers and cis-heterodimers with other CD300 family proteins, and the composition of these dimers affects the cellular response. Antibody cross?linking of LMIR5 induces mast cell granule release and cytokine production as well as its tyrosine phosphorylation of LMIR5 (in human). LMIR5 interacts with TIM1 and TIM4 which regulate T cell activation and are themselves binding partners. TIM1 interactions with LMIR5 mediate mast cell activation and the accumulation of neutrophils at sites of TIM1 up?regulation on damaged renal tubule epithelial cells. Acts as an activating immune receptor through its interaction with ITAM-bearing adapter TYROBP, and also independently by recruitment of GRB2.
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