蛋白质/抗原/多肽 >> 重组蛋白
重组HJURP蛋白
半岛bd体育手机客户端 介绍
基因名：
HJURP 半岛bd体育手机客户端 别名： FAKTS； URLC9； hFLEG1； HJURP； Holliday junction recognition protein； Holliday junction recognition protein； Holliday junction recognition protein； 14-3-3-associated AKT substrate； fetal liver expressing gene 1； fetal liver-expressing gene 1 protein； up-regulated in lung cancer 9； HJURP蛋白； 背景信息：
HJURP is a 748 amino acid protein that is expressed in thymus, placenta, small intestine, liver, skeletal muscle, bone marrow and colon. When histone H3-like variant CENP-A nucleosomes are assembled, HJURP localizes in centromeres during late telophase and early G1 phase, and localizes to the nucleolus during S phase. Considered a centromeric protein, HJURP plays a central role in the incorporation and maintenance of CENP-A at centromeres. HJURP also acts as a specific chaperone for CENP-A and is required for the incorporation of newly synthesized CENP-A molecules into nucleosomes at replicated centromeres. HJURP is considered an indispensable factor for chromosomal stability in immortalized cancer cells and is a potential novel therapeutic target for the development of anticancer drugs.
标签：His-tag |
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