半岛bd体育手机客户端 介绍
基因名：
RAPGEF2 半岛bd体育手机客户端 别名： CNrasGEF； NRAPGEP； PDZ-GEF1； PDZGEF1； RA-GEF； RA-GEF-1； RAGEF； Rap-GEP； nRap GEP； RAPGEF2； Rap guanine nucleotide exchange factor 2； Rap guanine nucleotide exchange factor 2； rap guanine nucleotide exchange factor 2； PDZ domain containing guanine nucleotide exchange factor (GEF) 1； PDZ domain-containing guanine nucleotide exchange factor 1； RA(Ras/Rap1A-associating)-GEF； Rap guanine nucleotide exchange factor (GEF) 2； cyclic nucleotide ras GEF； neural RAP guanine nucleotide exchange protein； ras/Rap1-associating GEF-1； Rap鸟嘌呤核苷酸交换因子2； 背景信息：
SummaryMembers of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RAPGEF2, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000 [PubMed 10934204]).[supplied by OMIM, Mar 2008]
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