蛋白质/抗原/多肽 >> 重组蛋白
重组环指蛋白105
半岛bd体育手机客户端 介绍
基因名：
TTC3 半岛bd体育手机客户端 别名： DCRR1； RNF105； TPRDIII； TTC3； tetratricopeptide repeat domain 3； tetratricopeptide repeat domain 3； E3 ubiquitin-protein ligase TTC3； RING finger protein 105； RING-type E3 ubiquitin transferase TTC3； TPR repeat protein 3； TPR repeat protein D； tetratricopeptide repeat protein 3； 环指蛋白105； 背景信息：
E3 ubiquitin-protein ligase that mediates the ubiquitination and subsequent degradation of phosphorylated Akt (AKT1, AKT2 and AKT3) in the nucleus. Acts as a terminal regulator of Akt signaling after activation; its phosphorylation by Akt, which is a prerequisite for ubiquitin ligase activity, suggests the existence of a regulation mechanism required to control Akt levels after activation. Catalyzes the formation of 'Lys-48'-polyubiquitin chains. May play a role in neuronal differentiation inhibition via its interaction with CIT.
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