半岛bd体育手机客户端 介绍
基因名：
SLC20A2 半岛bd体育手机客户端 别名： GLVR-2； GLVR2； IBGC1； IBGC2； IBGC3； MLVAR； PIT-2； PIT2； RAM1； Ram-1； SLC20A2； solute carrier family 20 member 2； solute carrier family 20 member 2； sodium-dependent phosphate transporter 2； epididymis secretory sperm binding protein； gibbon ape leukemia virus receptor 2； murine leukemia virus, amphotropic, receptor for； murine leukemia virus, amphotropic; receptor； solute carrier family 20 (phosphate transporter), member 2； 溶质载体蛋白家族20成员2； 背景信息：
The SLC20 family transport proteins were originally identified as retroviral receptors Glvr-1 and Ram-1, but are now designated sodium-dependent phosphate transporters 1 and 2 (PiT1 and PiT2). The PiT proteins function as sodium-phosphate cotransporters and are widely expressed, with high expression in bone, kidney and intestine. Both PiT1 and PiT2 are expressed on polarized epithelial cell membranes where they play a role in cellular phosphate homeostasis. PiT2 is a human receptor for amphotropic murine leukemia virus (A-MuLV). A-MuLV infects a variety of mammalian cell lines, including humans, making it a useful tool in gene transfer technology and as a vector for gene therapy. Retroviral vector systems are used in gene therapy that are designed to infect cells expressing PiT1 or PiT2.
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