蛋白质/抗原/多肽 >> 重组蛋白
重组神经肿瘤Nova2抗原蛋白
半岛bd体育手机客户端 介绍
基因名：
NOVA2 半岛bd体育手机客户端 别名： ANOVA； NEDASB； NOVA-2； NOVA3； NOVA2； NOVA alternative splicing regulator 2； NOVA alternative splicing regulator 2； RNA-binding protein Nova-2； astrocytic NOVA1-like RNA-binding protein； neuro-oncological ventral antigen 2； neuro-oncological ventral antigen 3； 神经肿瘤Nova2抗原； 背景信息：
Nova-1 and Nova-2 are members of a superfamily of protein regulators of RNA metabolism in neurons. Both are nuclear RNA binding proteins with K homology motifs, conserved protein sequences which bind to RNA (1,2). Nova proteins, normally sequestered in the central nervous system, are expressed by systemic tumors in patients with the autoimmune disorder paraneoplastic opsoclonus-myoclonus ataxia (POMA) (3,4). Nova-1 is expressed in the hindbrain and ventral spinal cord and Nova-2 is expressed in the neocortex and hippocampus (4). Nova-1 is necessary for regulating neuron-specific alternative splicing of the glycine receptor Alpha2 pre-mRNA (5).
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