半岛bd体育手机客户端 介绍
基因名：
MS4A2 半岛bd体育手机客户端 别名： APY； ATOPY； FCER1B； FCERI； IGEL； IGER； IGHER； MS4A2； membrane spanning 4-domains A2； membrane spanning 4-domains A2； high affinity immunoglobulin epsilon receptor subunit beta； Fc fragment of IgE, high affinity I, receptor for; beta polypeptide； High affinity immunoglobulin epsilon receptor beta-subunit (FcERI) (IgE Fc receptor, beta-subunit) (Fc epsilon receptor I beta-chain)； high affinity IgE receptor beta subunit； igE Fc receptor subunit beta； immunoglobulin E receptor, high affinity, beta polypeptide； membrane-spanning 4-domains subfamily A member 2； 跨膜结构域4亚家族成员2； 背景信息：
The allergic response involves the binding of allergen to receptor-bound IgE followed by cell activation and the release of mediators responsible for the manifestations of allergy. The IgE-receptor, a tetramer composed of an alpha, beta, and 2 disulfide-linked gamma chains, is found on the surface of mast cells and basophils. This gene encodes the beta subunit of the high affinity IgE receptor which is a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This family member is localized to 11q12, among a cluster of membrane-spanning 4A gene family members. Alternative splicing results in multiple transcript variants encoding distinct proteins. Additional transcript variants have been described but require experimental validation. [provided by RefSeq, Mar 2012].
标签：His-tag |
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