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TRPV4 Antagonist II, HC-067047-Calbiochem
| 半岛bd体育手机客户端 编号： | 4170043 |
| 规格： | The TRPV4 Antagonist II, HC-067047 controls the biological activity of TRPV4. |
| 包装规格： | 10 MG |
| 半岛bd体育手机客户端 类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
半岛bd体育手机客户端 别名
TRPV4 Antagonist II, HC-067047-Calbiochem
HC067047, 2-Methyl-1-(3-morpholinopropyl)-5-phenyl-N-(3-(trifluoromethyl)phenyl)-1H-pyrrole-3-carboxamide, Transient Receptor Potential Vanilloid-4 Antagonist II
2-Methyl-1-(3-morpholinopropyl)-5-phenyl-N-(3-(trifluoromethyl)phenyl)-1H-pyrrole-3-carboxamide, Transient Receptor Potential Vanilloid-4 Antagonist II, HC067047
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 |
C
26H
28F
3N
3O
2
|
| Molecular weight |
471.51
|
| MDL number |
MFCD01571257
|
| General description【一般描述】 |
A pyrrolocarboxamide compound that potently antagonizes TRP (transient receptor potential) family cation channel TRPV4 activity (IC
50= 17, 48, and 133 nM, respectively, against mouse, human, or rat TRPV4 in whole cell voltage-gated current measurement) in a reversible manner, displaying much reduced potency against human ERG and TRPM8 (IC
50= 368 and 780 nM, respectively) and little or no activity toward hK
v1.3, hTRPA1, hTRPC5, hTRPV1/2/3/6, mTRPM7, mTRPV2, or rK
v1.2. HC-067047 is efficacious (10 mg/kg via i.p.) in reducing micturition (urination) frequency and increasing voided urine volume of mice and rats suffering from CPA- (Cat. No. 239785) induced cystitis
in vivo.
|
| Warning【警告】 |
Toxicity: Standard Handling (A)
|
| Reconstitution【重悬】 |
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
|
| Other Notes【其他说明】 |
Everaerts, W., et al. 2010.
Proc. Natl. Acad. Sci. USA
107,19084.
|
| Legal Information【法律信息】 |
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
|
半岛bd体育手机客户端 性质
| Quality Level【质量水平】 |
100
|
| Assay【测定】 |
≥98% (HPLC)
|
| form【形式】 |
solid
|
| manufacturer/tradename |
Calbiochem
?
|
| storage condition【储存条件】 |
OK to freeze
protect from light |
| color【颜色】 |
white
|
| solubility【溶解性】 |
DMSO: 50 mg/mL, clear, colorless
|
| shipped in【运输】 |
ambient
|
| storage temp.【储存温度】 |
2-8℃
|
| packaging【包装】 |
10 mg in Glass bottle
Packaged under inert gas |
安全信息
| Storage Class Code【储存分类代码】 |
11 - Combustible Solids
|
| WGK |
WGK 3
|
