您的位置：首页 > 半岛bd体育手机客户端 中心 > Topoisomerase IIα Inhibitor, TSC24-Calbiochem
Topoisomerase IIα Inhibitor, TSC24-Calbiochem
| 半岛bd体育手机客户端 编号： | 4169966 |
| 规格： | The Topoisomerase IIα Inhibitor, TSC24 controls the biological activity of Topoisomerase. This small molecule/inhibitor is primarily used for Cell Structure applications. |
| 包装规格： | 10 MG |
| 半岛bd体育手机客户端 类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
半岛bd体育手机客户端 别名
Topoisomerase IIα Inhibitor, TSC24-Calbiochem
(E)-N,N-dimethyl-2-(quinolin-2-ylmethylene)hydrazinecarbothioamide
基本信息
| Empirical Formula【经验(实验)分子式】 |
C
13H
14N
4S
|
| Molecular weight |
258.34
|
| General description【一般描述】 |
A cell-permeable, TSC (thiosemicarbazone) derivative that acts as a selective and ATP competitive Topoisomerase IIα inhibitor and Fe chelator. Independent of its Fe chelating ability, this compound is shown to block Topo II&alpha-catalyzed ATP hydrolysis by competing with ATP for binding to the ATPase domain of Topo IIα (K
d= 18 ?M). It also displays M phase cell-cycle arrest at 1 ?M in nocodazole-treated HT-29 cells. This compound demonstrates anti-proliferative activity, without distinct or obvious selectivity, towards HeLa, HL-60, SGC7901, and HT-29 cultures (IC
50= 90 nM, 50 nM, 30 nM, and 20 nM, respectively), and a broader panel of tumor cell lines with IC
50values in the nanomolar range.
|
| Warning【警告】 |
Toxicity: Standard Handling (A)
|
| Reconstitution【重悬】 |
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
|
| Other Notes【其他说明】 |
Huang, H., et al. 2010.
J. Med. Chem.
53,3048.
|
| Legal Information【法律信息】 |
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
|
半岛bd体育手机客户端 性质
| Quality Level【质量水平】 |
100
|
| Assay【测定】 |
≥95% (HPLC)
|
| form【形式】 |
powder
|
| manufacturer/tradename |
Calbiochem
?
|
| storage condition【储存条件】 |
OK to freeze
|
| color【颜色】 |
yellow
|
| solubility【溶解性】 |
DMSO: 15 mg/mL
|
| shipped in【运输】 |
wet ice
|
| storage temp.【储存温度】 |
?20℃
|
| packaging【包装】 |
10 mg in Glass bottle
|
安全信息
| Storage Class Code【储存分类代码】 |
11 - Combustible Solids
|
| WGK |
WGK 3
|
