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Topoisomerase II Inhibitor, BNS-22-Calbiochem
| 半岛bd体育手机客户端 编号： | 4169965 |
| 规格： | The Topoisomerase II Inhibitor, BNS-22 controls the biological activity of Topoisomerase. This small molecule/inhibitor is primarily used for Cell Structure applications. |
| 包装规格： | 10 MG |
| 半岛bd体育手机客户端 类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
半岛bd体育手机客户端 别名
Topoisomerase II Inhibitor, BNS-22-Calbiochem
BNS-22
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 |
C
24H
25NO
5
|
| Molecular weight |
407.46
|
| MDL number |
MFCD22628799
|
| General description【一般描述】 |
A potent, 2H-chromen-2-one small molecule inhibitor that is selective for TOP2 (IC
50= 2.8 ?M and 0.42 ?M for TOP2α and TOP2β, respectively). Unlike TOP2 poisons such as etoposide, it does not lead to DNA damage associated with DNA Double-Strand Breaks, as evidenced by the lack of γ-H2AX accumulation but instead inhibits kinetoplast DNA decatenation
in vitro. This compound affects cell cycle at the M phase and disturbs mitotic spindle formation in HeLa cells at 3-10 ?M. It also exhibits significant anti-proliferative activities against several human cancer cell lines.
|
| Warning【警告】 |
Toxicity: Standard Handling (A)
|
| Reconstitution【重悬】 |
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
|
| Other Notes【其他说明】 |
Kawatani, M., et al. 2011.
Chem Biol.
18,743.
|
| Legal Information【法律信息】 |
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
|
半岛bd体育手机客户端 性质
| Quality Level【质量水平】 |
100
|
| Assay【测定】 |
≥99% (HPLC)
|
| form【形式】 |
solid
|
| manufacturer/tradename |
Calbiochem
?
|
| storage condition【储存条件】 |
OK to freeze
protect from light |
| color【颜色】 |
white
|
| solubility【溶解性】 |
DMSO: 25 mg/mL, clear, colorless
|
| shipped in【运输】 |
ambient
|
| storage temp.【储存温度】 |
2-8℃
|
| packaging【包装】 |
10 mg in Glass bottle
Packaged under inert gas |
安全信息
| Storage Class Code【储存分类代码】 |
11 - Combustible Solids
|
| WGK |
WGK 3
|
