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Anti-REP-1 Antibody, clone 2F1
| 半岛bd体育手机客户端 编号： | 4154896 |
| 规格： | clone 2F1, from mouse |
| 包装规格： | 100 μG |
| 半岛bd体育手机客户端 类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
半岛bd体育手机客户端 别名
Anti-REP-1 Antibody, clone 2F1
choroideremia (Rab escort protein 1), choroideremia, Choroideraemia protein, Rab escort protein 1, Rab geranylgeranyltransferase component A, TCD protein
基本信息
| eCl@ss |
32160702
|
| NACRES |
NA.41
|
| General description【一般描述】 |
Rab proteins are low molecular weight, ras-related GTPases that bind to a cell membrane’s cytoplasmic surface and function to regulate protein trafficking in both endocytic and secretory pathways. Rab escort protein (REP)-1 is a 653 amino acid protein belonging to the Rab GDI family of proteins. REP-1 binds to newly assembled unprenylated RAB proteins, escorts them to the Rab GGTases, and remains attached during and after the geranylgeranyl transfer reaction. REP proteins are composed of two conserved domains connected by a 150 amino acid insert. The multisheet domain I acts to assemble a Rab-binding platform. A globular, smaller, α-helical domain II, is thought to participate in membrane-protein interaction. Defects in the expression of REP-1 cause truncation or absence of the protein, and result in a disease called choroideremia (CHM), an X-linked blindness characterized by a progressive dystrophy of the retinal pigment epithelium, retina, and the choroid.
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| Specificity【特异性】 |
This antibody recognizes REP-1.
|
| Immunogen【免疫原】 |
Recombinant protein corresponding to human REP-1.
|
| Application【应用】 |
Anti-REP-1 Antibody, clone 2F1 is an antibody against REP-1 for use in WB, IP, IC, IH.
Immunohistochemistry Analysis: A previous lot of MABN52 was successfully used in IH, as reported by an independent laboratory (MacDonald, I.M., et al. (2005). Invest Ophthalmol Vis Sci. 46:E-Abstract 540). |
| Quality【质量】 |
Evaluated by Western Blot in 293T cell lysate.
Western Blot Analysis: 0.5 ?g/mL of this antibody detected REP-1 on 10 ?g of 293T cell lysate. |
| Physical form【外形】 |
Protein G Purified
Format: Purified |
| Other Notes【其他说明】 |
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
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半岛bd体育手机客户端 性质
| Quality Level【质量水平】 |
100
|
| biological source【生物来源】 |
mouse
|
| antibody form【抗体形式】 |
purified immunoglobulin
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| antibody product type |
primary antibodies
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| clone【克隆】 |
2F1, monoclonal
|
| species reactivity |
human
|
| technique(s) |
immunocytochemistry: suitable
immunohistochemistry: suitable immunoprecipitation (IP): suitable western blot: suitable |
| isotype【同位素/亚型】 |
IgG1κ
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| NCBI accession no.【NCBI登记号】 |
NP_000381
|
| UniProt accession no.【UniProt登记号】 |
P24386
|
| shipped in【运输】 |
wet ice
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半岛bd体育手机客户端 说明
| Target description【目标描述】 |
~83 kDa observed
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| 【免责声明】 |
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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安全信息
| Storage Class Code【储存分类代码】 |
12 - Non Combustible Liquids
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| WGK |
WGK 1
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