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Anti-LAMP-3 Antibody, clone 16H11.2
| 半岛bd体育手机客户端 编号： | 4154555 |
| 规格： | clone 16H11.2, from mouse |
| 包装规格： | 100 μG |
| 半岛bd体育手机客户端 类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
半岛bd体育手机客户端 别名
Anti-LAMP-3 Antibody, clone 16H11.2
LAMP, CD208, LAMP-3, DC-loysosome-associated membrane glycoprotein, DC LAMP, DC-LAMP, Protein TSC403
基本信息
| eCl@ss |
32160702
|
| NACRES |
NA.41
|
| General description【一般描述】 |
Lysosyme-associated membrane proteins (LAMP) are transmembrane lysosomal glycoproteins, which share a common Gly-Tyr motif as a lysosomal targeting signal. While LAMP-1 and LAMP-2 contain type 1 transmembrane domains, LAMP-3 contains a transmembrane 4 superfamily domain, tetraspanin. FceRI-mediated stimulation of basophils causes LAMP-3 to be translocated from its intracellular localization to the plasma membrane. LAMP-3 thereby serves as a reliable marker for basophil activation. LAMP-3 expression is known to be reported in human bone marrow mast cells and in leukemic human mast cell line (HMC-1), among other cell lines. LAMP3 is shown to be regulated by hypoxia in a panel of tumor cells, via the unfolded protein response (UPR). UPR is a mechanism of adaptation to endoplasmic reticulum stress and is demonstrated to contribute to hypoxic adaptation in tumors through multiple mechanisms.
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| Immunogen【免疫原】 |
Recombinant protein corresponding to human LAMP-3.
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| Application【应用】 |
Research Category
Cell Structure Immunohistochemistry Analysis: A 1:200 dilution from a representative lot detected LAMP-3 in colorectal adenocarcinoma tissue. Research Sub Category Apoptosis - Additional Organelle & Cell Markers Detect LAMP-3 using this Anti-LAMP-3 Antibody, clone 16H11.2 validated for use in WB, IH. |
| Quality【质量】 |
Evaluated by Western Blot in MCF-7 cell lysate.
Western Blot Analysis: 1 ?g/mL of this antibody detected LAMP-3 in MCF-7 cell lysate. |
| Physical form【外形】 |
Purified mouse monoclonal IgG2bκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Format: Purified Protein G Purified |
| Analysis Note【分析说明】 |
Control
MCF-7 cell lysate |
| Other Notes【其他说明】 |
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
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半岛bd体育手机客户端 性质
| Quality Level【质量水平】 |
100
|
| biological source【生物来源】 |
mouse
|
| antibody form【抗体形式】 |
purified immunoglobulin
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| antibody product type |
primary antibodies
|
| clone【克隆】 |
16H11.2, monoclonal
|
| species reactivity |
human
|
| technique(s) |
immunohistochemistry: suitable
western blot: suitable |
| isotype【同位素/亚型】 |
IgG2bκ
|
| NCBI accession no.【NCBI登记号】 |
NP_055213
|
| UniProt accession no.【UniProt登记号】 |
Q9UQV4
|
| shipped in【运输】 |
wet ice
|
| Gene Information |
human ... LAMP3(27074)
|
半岛bd体育手机客户端 说明
| Target description【目标描述】 |
~65 kDa observed.
The calculated molecular weight of this protein is 41 kDa, but has been observed at ~65-90 kDa due to glycosolation (de Saint-Vis, B., et al. (1998). Immunity. 9(3):325-336). |
| Storage and Stability【储存及稳定性】 |
Stable for 1 year at 2-8°C from date of receipt.
|
| Disclaimer【免责声明】 |
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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安全信息
| Storage Class Code【储存分类代码】 |
12 - Non Combustible Liquids
|
| WGK |
WGK 1
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