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Anti-Integrin beta-3 Antibody
| 半岛bd体育手机客户端 编号： | 4154526 |
| 规格： | from rabbit, purified by affinity chromatography |
| 包装规格： | 100 μG |
| 半岛bd体育手机客户端 类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
半岛bd体育手机客户端 别名
Anti-Integrin beta-3 Antibody
integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61), Platelet membrane glycoprotein IIIa, integrin beta-3, platelet glycoprotein IIIa, CD61 antigen
基本信息
| eCl@ss |
32160702
|
| NACRES |
NA.41
|
| General description【一般描述】 |
Integrin beta-3 is a member of the Integrin receptor family. The integrin family has been shown to be instrumental in cell adhesion to extracellular matrix proteins and can be found in certain cell to cell adhesions. Integrins are also important in transmembrane connections and intracellular signaling. Integrins are key to understanding many human diseases as they are commonly the receptors. Integrins have been linked to many different parts of cellular operations including; development, immunity, leukocyte traffic, homeostasis and even cancer. Once integrin beta-3 is activated, it binds fibrinogen which causes platelet to platelet interaction effectively cutting off a ruptured endothelial surface.
|
| Specificity【特异性】 |
Other homologies: Mouse (93% sequence homology.)
This antibody recognizes the extracellular domain of integrin beta-3. |
| Immunogen【免疫原】 |
Epitope: Extracellular Domain
KLH-conjugated linear peptide corresponding to human integrin beta-3 at the extracellular domain. |
| Application【应用】 |
Research Category
Cell Structure Immunohistochemistry Analysis: A 1:500 dilution from a previous lot detected intergin beta-3 in skin membrane tissue. Immunoprecipitaiton Analysis: 10 ?g from a previous lot immunoprecipitated integrin beta-3 from U251 RIPA lysate. Anti-Integrin beta-3 Antibody is an antibody against Integrin beta-3 for use in WB, IP, IH(P). Research Sub Category ECM Proteins |
| Quality【质量】 |
Evaluated by Western Blot in U251 cell lysate.
Western Blot Analysis: 0.5 ?g/mL of this antibody detected integrin beta-3 in 10 ?g of U251 cell lysate. |
| Linkage【联系】 |
Replaces: 04-1060
|
| Physical form【外形】 |
Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Affinity purified |
| Analysis Note【分析说明】 |
Control
U251 cell lysate |
| Other Notes【其他说明】 |
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
|
半岛bd体育手机客户端 性质
| biological source【生物来源】 |
rabbit
|
| Quality Level【质量水平】 |
100
|
| antibody form【抗体形式】 |
affinity isolated antibody
|
| antibody product type |
primary antibodies
|
| clone【克隆】 |
polyclonal
|
| purified by【纯化方式】 |
affinity chromatography
|
| species reactivity |
pig, human
|
| species reactivity (predicted by homology) |
porcine (based on 100% sequence homology), chimpanzee (based on 100% sequence homology), bovine (based on 100% sequence homology), canine (based on 100% sequence homology), rat (based on 100% sequence homology)
|
| technique(s) |
immunohistochemistry: suitable (paraffin)
immunoprecipitation (IP): suitable western blot: suitable |
| NCBI accession no.【NCBI登记号】 |
NP_000203
|
| UniProt accession no.【UniProt登记号】 |
P05106
|
| shipped in【运输】 |
wet ice
|
| Gene Information |
human ... ITGB3(3690)
|
半岛bd体育手机客户端 说明
| Target description【目标描述】 |
~85 kDa observed.
Uncharacterized bands may be observed in some lysates. |
| Storage and Stability【储存及稳定性】 |
Stable for 1 year at 2-8°C from date of receipt.
|
| Disclaimer【免责声明】 |
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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安全信息
| Storage Class Code【储存分类代码】 |
12 - Non Combustible Liquids
|
| WGK |
WGK 1
|
