您的位置：首页 > 半岛bd体育手机客户端 中心 > 171744-11-9， GGTI-286-CAS 171744-11-9-Calbiochem
GGTI-286-CAS 171744-11-9-Calbiochem
| 半岛bd体育手机客户端 编号： | 4144961 |
| 规格： | A potent, cell-permeable, and selective inhibitor of GGTase I. |
| CAS NO： | 171744-11-9 |
| 包装规格： | 250 μG |
| 半岛bd体育手机客户端 类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
半岛bd体育手机客户端 价格
查看更多规格...
| 半岛bd体育手机客户端 编号 | 包装单位 | 单价(元) | 国内现货 | 国外库存 | 询价单 |
| 4144961 | 250 μG | 3010 |
半岛bd体育手机客户端 别名
171744-11-9
GGTI-286-CAS 171744-11-9-Calbiochem
N-4-[2(R)-Amino-3-mercaptopropyl]amino-2-phenylbenzoyl-(L)-leucine methyl ester, TFA
基本信息
| Empirical Formula【经验(实验)分子式】 |
C
23H
31N
3O
3S
|
| Molecular weight |
429.58
|
| General description【一般描述】 |
A potent, cell-permeable, and selective GGTase-I inhibitor. This methyl ester derivative of GGTI-287 (Cat. No. 345880) is 25-fold more potent (IC
50= 2 ?M versus 50 ?M) than FTI-277 (Cat. No. 344555) inhibiting the processing of the geranylgeranylated protein Rap1A. Selectively antagonizes oncogenic K-Ras4B (IC
50= 2 ?M). GGTI-286 has also been shown to have a significant antiproliferative effect in human malignant glioma cells.
A potent, cell-permeable, and selective inhibitor of GGTase I. This methyl ester derivative of GGTI-287 (Cat. No. 345880) is about 25-fold more potent (IC 50= 2 ?M vs. 50 ?M) than FTI-277 (Cat. No. 344555) in inhibiting the processing of the geranylgeranylated protein Rap1A. Selectively antagonizes oncogenic K-Ras4B (IC 50= 2 ?M). GGTI-286 has also been shown to have a significant antiproliferative effect in human malignant glioma cells. |
| Biochem/physiol Actions【生化/生理作用】 |
Target IC
50: 2 ?M against GGTase
Product does not compete with ATP. Cell permeable: yes Primary Target Geranylgeranyltransferase (GGTase) Reversible: no |
| Warning【警告】 |
Toxicity: Standard Handling (A)
|
| Physical form【外形】 |
Supplied as a trifluoroacetate salt.
|
| Reconstitution【重悬】 |
Following reconstitution aliquot and freeze (-70°C). Stock solutions are stable for up to 1 week at -70°C.
|
| Other Notes【其他说明】 |
Bredel, M., et al. 1998.
Neurosurgery
43,124.
Qian, Y., et al. 1998. Bioorg. Med. Chem. 6,293. Lerner, E.C., et al. 1997. Oncogene 15,1283. Lerner, E.C., et al. 1995. J. Biol. Chem. 270,26770. |
| Legal Information【法律信息】 |
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
|
半岛bd体育手机客户端 性质
| Quality Level【质量水平】 |
100
|
| Assay【测定】 |
≥90% (HPLC)
|
| form【形式】 |
solid (Glassy)
|
| manufacturer/tradename |
Calbiochem
?
|
| storage condition【储存条件】 |
OK to freeze
|
| solubility【溶解性】 |
DMSO: 10 mg/mL
|
| shipped in【运输】 |
ambient
|
| storage temp.【储存温度】 |
?20℃
|
| packaging【包装】 |
250 μg in Plastic ampoule
Packaged under inert gas |
安全信息
| Storage Class Code【储存分类代码】 |
10 - Combustible liquids
|
| WGK |
WGK 3
|
