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Phthalimidooxy-dPEG®12-NHS ester
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C39H60N2O19 |
| Molecular weight | 860.90 |
| MDL number | MFCD21363338 |
| PubChem Substance ID【PubChem化学物质编号】 | 329823971 |
| Features and Benefits【特点和优势】 | Phthalimidooxy-dPEG®12-NHS ester allows introduction of an oxyamine function onto a target molecule for cross-linking proteins or for creating stable conjugates with the target molecule. The oxyamine function is protected by a phthalimido protecting group on one end of the spacer arm, and the spacer is installed on the target molecule with the amine-reactive N-hydroxysuccinimide (NHS) group on the other end of the spacer. The single molecular weight dPEG® spacers have precise length for spatial control. They are hydrophilic and non-immunogenic. The dPEG® spacers improve water solubility and reduce aggregation and precipitation of proteins. The phthalimido protecting group can be removed using hydrazine. The oxyamine group exposed after deprotection can be reacted with an aldehyde- or ketone-containing molecule to form an oxime bond linking the two molecules. These reagents can be used with any protein, peptide, or small molecule that has a free amine. |
| Legal Information【法律信息】 | Products Protected under U.S. Patents # 7,888,536 B2 dPEG is a registered trademark of Quanta BioDesign |
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性质
| Assay【测定】 | >90% |
| form【形式】 | solid or viscous liquid |
| reaction suitability | reagent type: cross-linking reagent reactivity: amine reactive reagent type: cross-linking reagent reactivity: thiol reactive |
| polymer architecture【聚合物结构设计】 | shape: linear functionality: heterobifunctional |
| shipped in【运输】 | ambient |
| storage temp.【储存温度】 | −20℃ |
| SMILES string | O=C(CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCON1C(C2=C(C1=O)C=CC=C2)=O)ON3C(CCC3=O)=O |
安全信息
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
