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FKBP-8 Antibody
| 半岛bd体育手机客户端 编号： | 4118694 |
| 规格： | serum, from rabbit |
| 包装规格： | 100 μL |
| 半岛bd体育手机客户端 类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
半岛bd体育手机客户端 别名
FKBP-8 Antibody
Peptidyl-prolyl cis-trans isomerase FKBP8, PPIase FKBP8, 38 kDa FK506-binding protein, 38 kDa FKBP, FKBP-38, hFKBP38, FK506-binding protein 8, FKBP-8, FKBPR38, Rotamase
基本信息
| eCl@ss |
32160702
|
| NACRES |
NA.41
|
| General description【一般描述】 |
FKBP-8, also known as Peptidyl-prolyl cis-trans isomerase PPIase FKBP8, FKBP8, 38 kDa FK506-binding protein, 38 kDa FKBP, FKBP-38, hFKBP38, FK506-binding protein 8, FKBP-8, FKBPR38, Rotamase, is encoded by the gene name FKBP8 and FKBP38. FKBP-8 is in constitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Recent studies have shown that FKBP-8 may act as a chaperone for BCL2, by targeting BCL2 to the mitochondria and modulating its phosphorylation state. Furthermore, the BCL2/FKBP8/calmodulin/calcium complex may play a role in the binding of BCL2 to its targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis. FKBP-8 is expressed widely, with highest levels detected in brain. FKBP-8 is also highly abundant in the retina.
|
| Immunogen【免疫原】 |
Epitope: N-terminus
Recombinant protein corresponding to the N-terminus of human FKBP-8. |
| Application【应用】 |
Western Blotting Analysis: A representative lot detected FKBP-8 in HeLa transfected with myc-FKBP38 and HEK293 cell lysate (Zou, H., et al. (2013). JBC. 1-9).
Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected FKBP-8 in human cerebral cortex and human thalamus tissue. Research Category Signaling Research Sub Category Signaling Neuroscience This FKBP-8 antibody is validated for use in WB, IH for the detection of FKBP-8. |
| Quality【质量】 |
Evaluated by Western Blotting in HeLa cell lysate.
Western Blotting Analysis: A 1:1,000 dilution of this antibody detected FKBP-8 in 10 ?g of HeLa cell lysate. |
| Physical form【外形】 |
Rabbit polyclonal serum with 0.05% sodium azide.
Unpurified |
| Other Notes【其他说明】 |
Concentration: Please refer to lot specific datasheet.
|
半岛bd体育手机客户端 性质
| biological source【生物来源】 |
rabbit
|
| Quality Level【质量水平】 |
100
|
| antibody form【抗体形式】 |
serum
|
| clone【克隆】 |
polyclonal
|
| species reactivity |
human
|
| technique(s) |
immunohistochemistry: suitable
western blot: suitable |
| NCBI accession no.【NCBI登记号】 |
NP_036313
|
| UniProt accession no.【UniProt登记号】 |
Q14318
|
| shipped in【运输】 |
dry ice
|
半岛bd体育手机客户端 说明
| Target description【目标描述】 |
~60 kDa observed. The calculated molecular weight is 44 kDa, however FKBP-8 has been shown at ~53-62 kDa most likely due to post-translational modification.
|
| Storage and Stability【储存及稳定性】 |
Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. |
| Disclaimer【免责声明】 |
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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安全信息
| Storage Class Code【储存分类代码】 |
10 - Combustible liquids
|
| WGK |
WGK 1
|
