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FADD, His tagged human
| 半岛bd体育手机客户端 编号： | 4118603 |
| 规格： | recombinant, expressed inE. coli, ≥70% (SDS-PAGE), buffered aqueous glycerol solution |
| CAS NO： | 2172914-14-4 |
| 包装规格： | 50 μG |
| 半岛bd体育手机客户端 类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
半岛bd体育手机客户端 别名
2172914-14-4
FADD, His tagged human
MGC8528
MORT1
GIG3
基本信息
| NACRES |
NA.32
|
| General description【一般描述】 |
FADD or Fas-Associated protein with Death Domain is an adaptor molecule that mediates death signaling by the Fas-receptor, tumor necrosis factor receptor and TRAIL-receptor. FADD binds to these receptors via the C-terminus Death Domain which then unmasks the N-terminal effector domain of FADD thereby allowing it to recruit caspase-8 and activate the cysteine protease cascade leading to apoptosis. Cells lacking FADD are defective in intracellular double-stranded RNA (dsRNA)-activated gene expression, including production of type I (alpha/beta) interferons and are thus very susceptible to viral infection.
|
| Physical form【外形】 |
Supplied in 50mM sodium phosphate, pH 7.0, 300mM NaCl, 150mM imidazole, 0.1mM PMSF, 0.25mM DTT, 25% glycerol.
|
| Preparation Note【制备说明】 |
after opening, aliquot into smaller quantities and store at -70 ℃. Avoid repeating handling and multiple freeze/thaw cycles
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半岛bd体育手机客户端 性质
| biological source【生物来源】 |
human
|
| recombinant【重组】 |
expressed in
E. coli
|
| Assay【测定】 |
≥70% (SDS-PAGE)
|
| form【形式】 |
buffered aqueous glycerol solution
|
| mol wt【分子量】 |
~27 kDa
|
| NCBI accession no.【NCBI登记号】 |
NM_003824
|
| application(s) |
cell analysis
|
| shipped in【运输】 |
dry ice
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| storage temp.【储存温度】 |
?70℃
|
| Gene Information |
human ... FADD(8772)
|
安全信息
| Pictograms【象形图】 |
GHS07,GHS08
|
| Signal word【警示用语：】 |
Danger
|
| Hazard Statements |
H315 - H319 - H360D
|
| Precautionary Statements |
P202 - P264 - P280 - P302 + P352 - P305 + P351 + P338 - P308 + P313
|
| Hazard Classifications【危险分类】 |
Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2
|
| Storage Class Code【储存分类代码】 |
6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
|
| WGK |
WGK 1
|
