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BTK (C481S), Active
半岛bd体育手机客户端 编号: | 4116972 |
规格: | PRECISIO?Kinase, recombinant |
包装规格: | 10 μG |
半岛bd体育手机客户端 类别: | 进口试剂 |
品牌: | Sigma-Aldrich |
优惠价: | 立即咨询 |
半岛bd体育手机客户端 性质
recombinant【重组】 |
expressed in baculovirus infected
Sf9 cells
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Assay【测定】 |
70-95% (SDS-PAGE)
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form【形式】 |
frozen liquid
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Specific Activity |
40-56 nmol/min·mg (radiometric)
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mol wt【分子量】 |
~75 kDa
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concentration【浓度】 |
0.1 μg/μL
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accession no.【登记号】 |
NM_005228
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shipped in【运输】 |
dry ice
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storage temp.【储存温度】 |
?70℃
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基本信息
Application【应用】 |
Useful for kinase assay and Western blot.
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Biochem/physiol Actions【生化/生理作用】 |
Recombinant full-length human BTK (C481S) was expressed by
Baculovirusin Sf9 insect cells using an N-terminal His tag. BTK (also known as Bruton tyrosine kinase) plays a crucial role in B-lymphocyte differentiation and activation. BTK interacts with SRC homology 3 domains of FYN, LYN and HCK that are activated upon stimulation of B- and T-cell receptors
(1).Defects in the BTK gene cause Agammaglobulinemia, an X-linked immunodeficiency characterized by failure to produce mature B lymphocyte cells and associated with a failure of Ig heavy chain rearrangement. The unique role of BTK makes it a desirable target for potential anti-cancer, anti-inflammatory and anti-viral agents as well as other treatments
(2).
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Reconstitution【重悬】 |
Formulated in 50mM sodium phosphate, pH 7.0, 300mM NaCl, 150mM imidazole, 0.1mM PMSF, 0.25mM DTT, with 25% glycerol.
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Legal Information【法律信息】 |
PRECISIO is a registered trademark of sigma-aldrich Co. LLC
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半岛bd体育手机客户端 说明
Storage and Stability【储存及稳定性】 |
Store in aliquots at -70℃. Avoid freeze/thaw cycles.
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安全信息
Pictograms【象形图】 |
GHS07,GHS08
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Signal word【警示用语:】 |
Danger
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Hazard Statements |
H315 - H319 - H360D
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Precautionary Statements |
P202 - P264 - P280 - P302 + P352 - P305 + P351 + P338 - P308 + P313
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Hazard Classifications【危险分类】 |
Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2
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Storage Class Code【储存分类代码】 |
6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
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WGK |
WGK 1
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