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BTK (C481S), Active

半岛bd体育手机客户端 编号: 4116972
规格: PRECISIO?Kinase, recombinant
包装规格: 10 μG
半岛bd体育手机客户端 类别: 进口试剂
品牌: Sigma-Aldrich
优惠价: 立即咨询
半岛bd体育手机客户端 价格
半岛bd体育手机客户端 编号 包装单位 单价(元) 国内现货 国外库存 询价单
4116972 10 μG 5170
半岛bd体育手机客户端 性质
recombinant【重组】
expressed in baculovirus infected Sf9 cells
Assay【测定】
70-95% (SDS-PAGE)
form【形式】
frozen liquid
Specific Activity
40-56 nmol/min·mg (radiometric)
mol wt【分子量】
~75 kDa
concentration【浓度】
0.1 μg/μL
accession no.【登记号】
NM_005228
shipped in【运输】
dry ice
storage temp.【储存温度】
?70℃
基本信息
Application【应用】
Useful for kinase assay and Western blot.
Biochem/physiol Actions【生化/生理作用】
Recombinant full-length human BTK (C481S) was expressed by Baculovirusin Sf9 insect cells using an N-terminal His tag. BTK (also known as Bruton tyrosine kinase) plays a crucial role in B-lymphocyte differentiation and activation. BTK interacts with SRC homology 3 domains of FYN, LYN and HCK that are activated upon stimulation of B- and T-cell receptors (1).Defects in the BTK gene cause Agammaglobulinemia, an X-linked immunodeficiency characterized by failure to produce mature B lymphocyte cells and associated with a failure of Ig heavy chain rearrangement. The unique role of BTK makes it a desirable target for potential anti-cancer, anti-inflammatory and anti-viral agents as well as other treatments (2).
Reconstitution【重悬】
Formulated in 50mM sodium phosphate, pH 7.0, 300mM NaCl, 150mM imidazole, 0.1mM PMSF, 0.25mM DTT, with 25% glycerol.
Legal Information【法律信息】
PRECISIO is a registered trademark of sigma-aldrich Co. LLC
半岛bd体育手机客户端 说明
Storage and Stability【储存及稳定性】
Store in aliquots at -70℃. Avoid freeze/thaw cycles.
安全信息
Pictograms【象形图】
GHS07,GHS08
Signal word【警示用语:】
Danger
Hazard Statements
H315 - H319 - H360D
Precautionary Statements
P202 - P264 - P280 - P302 + P352 - P305 + P351 + P338 - P308 + P313
Hazard Classifications【危险分类】
Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2
Storage Class Code【储存分类代码】
6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 1
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