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Anti-TRIM5 alpha antibody produced in rabbit
| 半岛bd体育手机客户端 编号： | 4115522 |
| 规格： | affinity isolated antibody |
| 包装规格： | 100 μG |
| 半岛bd体育手机客户端 类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
半岛bd体育手机客户端 性质
| biological source【生物来源】 |
rabbit
|
| Quality Level【质量水平】 |
100
|
| conjugate【偶联物】 |
unconjugated
|
| antibody form【抗体形式】 |
affinity isolated antibody
|
| antibody product type |
primary antibodies
|
| clone【克隆】 |
polyclonal
|
| form【形式】 |
liquid
|
| species reactivity |
human
|
| concentration【浓度】 |
1 mg/mL
|
| technique(s) |
immunofluorescence: suitable
immunohistochemistry: suitable western blot: suitable |
| isotype【同位素/亚型】 |
IgG
|
| NCBI accession no.【NCBI登记号】 |
NP_149023
|
| UniProt accession no.【UniProt登记号】 |
Q9C035
|
| shipped in【运输】 |
wet ice
|
| storage temp.【储存温度】 |
?20℃
|
| Gene Information |
human ... TRIM5(85363)
|
基本信息
| General description【一般描述】 |
TRIM5 alpha Antibody: TRIM5 is a member of a broad family of otherwise unrelated proteins defined by the presence of a tripartite motif containing a RING domain, a B-box type 1, and a B-box type 2, followed by a coiled-coil region. TRIM5 has six alternately spliced isoforms, the longest of which is the alpha variant which also contains a carboxy-terminal B30.2 (SPRY) domain. Expression of TRIM5α variants from humans, rhesus monkeys, and African green monkeys enabled resistance to infection by various retroviruses including HIV-1, albeit at differing efficiencies. All TRIM5α variants could inhibit at least two different retroviruses, but not from those viruses isolated from the same species, suggesting that TRIM5α acts as a natural barrier to cross-species retrovirus transmission.
|
| Immunogen【免疫原】 |
TRIM5 alpha antibody was raised against a synthetic peptide corresponding to amino acids near the mid-region of human TRIM5 alpha.The immunogen is located within amino acids 370 - 420 of TRIM5 alpha.
|
| Application【应用】 |
TRIM5 alpha antibody can be used for detection of TRIM5 alpha by Western blot at 2 μg/mL. A band at approximately 55 kDa can be detected. Antibody can also be used for immunohistochemistry starting at 2 μg/mL. For immunofluorescence start at 10 μg/mL.Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
|
| Physical form【外形】 |
Supplied in PBS containing 0.02% sodium azide.
|
安全信息
| Storage Class Code【储存分类代码】 |
12 - Non Combustible Liquids
|
| WGK |
nwg
|
