Anti-Phospho-PDHA1-S293 antibody produced in rabbit

rabbit

100

primary antibodies

monoclonal

liquid

rat, mouse, human

0.49 mg/mL

immunohistochemistry: 1:50-1:200
western blot: 1:500-1:2000

P08559

wet ice

−20℃

human ... PDHA1(5160)

The pyruvate dehydrogenase (PDH) complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle. The PDH complex is composed of multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). The E1 enzyme is a heterotetramer of two alpha and two beta subunits. This gene encodes the E1 alpha 1 subunit containing the E1 active site, and plays a key role in the function of the PDH complex. Mutations in this gene are associated with pyruvate dehydrogenase E1-alpha deficiency and X-linked Leigh syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2010]

A phospho specific peptide corresponding to residues surrounding S293 of human PDHA1

Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.