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Anti-APC8 Antibody
| 半岛bd体育手机客户端 编号： | 4104932 |
| 规格： | from rabbit, purified by affinity chromatography |
| 包装规格： | 100 μG |
| 半岛bd体育手机客户端 类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
半岛bd体育手机客户端 别名
Anti-APC8 Antibody
Cell division cycle protein 23 homolog, Anaphase-promoting complex subunit 8, APC8, Cyclosome subunit 8
基本信息
| eCl@ss |
32160702
|
| NACRES |
NA.41
|
| General description【一般描述】 |
Cell division cycle protein 23 homolog, also known as Anaphase-promoting complex subunit 8 (APC8) or Cyclosome subunit 8, and encoded by the gene name CDC23 or ANAPC8, is a highly conserved component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. APC/C is responsible for degrading anaphase inhibitors, mitotic cyclins, and spindle-associated proteins ensuring that events of mitosis take place in proper sequence. The individual APC/C components mRNA and protein levels are expressed at approximately the same levels in most tissues and cell lines, suggesting that they perform their functions as part of a complex. In Drosophila, silencing of APC8 results in developmental delay and pupal lethality with elevated levels of apoptosis, high mitotic index, and delayed or blocked mitosis.
|
| Immunogen【免疫原】 |
KLH-conjugated synthetic peptide corresponding to the center region of human APC8.
Epitope: center region |
| Application【应用】 |
Immunocytochemistry Analysis: 5 μg/mL from a representative lot detected APC8 in K562 cells.
Research Sub Category Cell Cycle, DNA Replication & Repair Detect APC8 using this Anti-APC8 Antibody validated for use in western blotting & ICC. Research Category Epigenetics & Nuclear Function |
| Quality【质量】 |
Evaluated by Western Blotting in K562 cell lysate.
Western Blotting Analysis: 2 μg/mL of this antibody detected APC8 in K562 cell lysate. |
| Physical form【外形】 |
Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.
Antigen Affinity Purified |
| Other Notes【其他说明】 |
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
|
半岛bd体育手机客户端 性质
| biological source【生物来源】 |
rabbit
|
| Quality Level【质量水平】 |
100
|
| antibody form【抗体形式】 |
affinity isolated antibody
|
| antibody product type |
primary antibodies
|
| clone【克隆】 |
polyclonal
|
| purified by【纯化方式】 |
affinity chromatography
|
| species reactivity |
human
|
| technique(s) |
immunocytochemistry: suitable
western blot: suitable |
| UniProt accession no.【UniProt登记号】 |
Q9UJX2
|
| shipped in【运输】 |
wet ice
|
半岛bd体育手机客户端 说明
| Target description【目标描述】 |
~55 kDa observed. Uncharacterized bands may be observed in some lysate(s). Uniprot describes 3 isoforms produced by alternative splicing at ~17 kDa, ~56 kDa, and ~69 kDa
|
| Storage and Stability【储存及稳定性】 |
Stable for 1 year at 2-8°C from date of receipt.
|
| Disclaimer【免责声明】 |
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
|
安全信息
| Storage Class Code【储存分类代码】 |
10 - Combustible liquids
|
| WGK |
WGK 2
|
