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SPL-334
| 半岛bd体育手机客户端 编号： | 4087046 |
| 规格： | ≥98% (HPLC) |
| CAS NO： | 688347-51-5 |
| 包装规格： | 5 MG，25 MG |
| 半岛bd体育手机客户端 类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
半岛bd体育手机客户端
别名
688347-51-5
SPL-334
4-{[2-[(2-Cyanobenzyl)thio]-4-oxothieno[3,2-d]pyrimidin-3(4H)-yl]methyl}benzoic acid
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C22H15N3O3S2 |
| Molecular weight | 433.50 |
| MDL number | MFCD05032783 |
| NACRES | NA.77 |
| Biochem/physiol Actions【生化/生理作用】 | SPL-334 is an inhibitor of S-Nitrosoglutathione reductase (GSNOR), the enzyme responsible for regulating cellular concentrations of S-Nitrosoglutathione (GSNO), which plays a critical role in nitric oxide signaling in the respiratory tract. In a mouse model of allergic airway inflammation, SPL-334 reduced airway hyperreactivity, and in a bleomycin injury model of interstitial lung disease, SPL-334 reduced lung inflammation and fibrosis. Studies for treatment of asthma, idiopathic pulmonary fibrosis (IPF), and inflammation are ongoing. |
半岛bd体育手机客户端
性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| color【颜色】 | white to beige |
| solubility【溶解性】 | DMSO: 20 mg/mL, clear |
| storage temp.【储存温度】 | 2-8℃ |
| SMILES string | OC(C1=CC=C(CN2C(SCC3=CC=CC=C3C#N)=NC(C=CS4)=C4C2=O)C=C1)=O |
| packaging【包装】 | 5, 25 mg in glass bottle |
安全信息
| Hazard Statements | H413 |
| Hazard Classifications【危险分类】 | Aquatic Chronic 4 |
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
