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16:0(2R-OH) Ceramide
| 半岛bd体育手机客户端 编号： | 4085921 |
| 规格： | N-(2′-(R)-hydroxypalmitoyl)-D-erythro-sphingosine, powder |
| CAS NO： | 34839-02-6 |
| 包装规格： | 5 MG |
| 半岛bd体育手机客户端 类别： | 进口试剂 |
| 品牌： | Avanti |
| 优惠价： | 立即咨询 |
半岛bd体育手机客户端 别名
34839-02-6
16:0(2R-OH) Ceramide
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 |
C
34H
67NO
4
|
| Molecular weight |
553.90
|
| NACRES |
NA.25
|
| General description【一般描述】 |
Ceramides with 2-hydroxy fatty acids (hFA) group are present in the epidermis. 16:0(2
R-OH) Ceramide is a unique ceramide containing 16C long chain base fatty acid (palmitic acid)-with 2′-hydroxyl group in R configuration.
|
| Biochem/physiol Actions【生化/生理作用】 |
Hydroxy fatty acid (hFA)-sphingolipids are implicated in cell signaling. They may also help in regulation of cell differentiation and apoptosis. Synthetic 2′
R-hydroxy-C16-ceramide exhibits high proapoptotic activity than proapoptotic 2′
S-hydroxy-C16-ceramide. hFA-ceramides in epidermis support permeability barrier function. hFA-ceramides are synthesized by fatty acid 2-hydroxylase (FA2H). Mutations of FA2H causes neurological disorders including, leukodystrophy and spastic paraparesis in humans. The mechanism of action for an antitumor drug, PM02734 involves hFA-ceramides in the cell membrane.
|
半岛bd体育手机客户端 性质
| form【形式】 |
powder
|
| manufacturer/tradename |
Avanti Polar Lipids 860815P
|
| shipped in【运输】 |
dry ice
|
| storage temp.【储存温度】 |
?20℃
|
| SMILES string |
CCCCCCCCCCCCC/C=C/[C@@H](O)[C@@H](NC([C@H](O)CCCCCCCCCCCCCC)=O)CO
|
| packaging【包装】 |
5 mL Amber Glass Screw Cap Vial (860815P-5mg)
5 mL Amber Glass Screw Cap Vial (860815P-25mg) |
安全信息
| Storage Class Code【储存分类代码】 |
13 - Non Combustible Solids
|
| WGK |
WGK 3
|
